Most patients begin on a low starting dose and gradually move up based on tolerance and weight loss response
A year later, that business has taken off
For maximum weight loss, tirzepatide still leads, though Lilly's pipeline includes oral tirzepatide-equivalent dual agonists that may close the gap in 2027-2028
Sarah Armstrong, a member of the AAP guideline committee, stated in a 2023 AAP press briefing: "We do not have the evidence to support pharmacotherapy with GLP-1 agonists below age 12, and clinicians should not extrapolate from adolescent data to younger children without trial-level safety evidence." The Endocrine Society's pediatric obesity guideline similarly restricts pharmacotherapy recommendations to adolescents aged 12 and older when lifestyle interventions have been insufficient [7]
Geng P, Ye F,Dou P,Hu C,He J, Li QBM, Li X, Liu X,Xu G