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Its reasoning is that cannabis and GLP-1 medications both act on nausea, appetite, and gastrointestinal function, so combining them can produce additive or unpredictable effects

Extensive research on POCS contributing factors highlighted obesity, elevated testosterone levels, fasting insulin levels, reduced sex hormone-binding globulin (SHBG), menopausal timing, and depression as the main contributors [3]

[3] [4] Understanding its effects on liver enzymes is important for both patients and healthcare providers, particularly given the high prevalence of fatty liver disease in populations with obesity and diabetes

Others have side effects that make treatment difficult to continue

Read the guide 2026 Update What changed for Washington Medicare beneficiaries this year premiums, deductibles, out-of-pocket caps, and formulary shifts worth knowing about