A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines
To this end, we synthesized a number of permethylated quinolinium analogues[17] guided by in silico calculation of partition coefficient (clogP).[26] Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity)[17] only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 1)
Our peptides are delivered as lyophilized (freeze-dried) powders, which are resistant to short-term temperature fluctuations during transport
Its like comparing apples and oranges tricky stuff
Quay TAW, Schroder TH, Jeruszka-Bielak M, Li W, Devlin AM, Barr SI, et al
