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Men and women with MTNR1B-related circadian disruption may find that sleep optimization, consistent sleep-wake timing, and light management have disproportionately large effects on libido relative to their apparent severity because the circadian genetic architecture was already at a lower baseline, making marginal circadian improvements produce larger-than-expected libido gains

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Previous research identified that lncRNA lnc-MRGPRF-6:1 promotes ox-LDL-induced macrophage ferroptosis by inhibiting GPX4