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Studies commonly focus on tendon and ligament injury models, muscle damage, wound healing, and gut irritation or ulcer models

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Consequently, the gutkidney axis can be understood as a unified framework, mediated by immune and metabolic pathways, that links gut immunity with microbial metabolism, thereby opening new avenues for immune-modulatory strategies beyond traditional pharmacological approaches ( 3.2 Gut barrier dysfunction and endotoxin translocation The gut barrier is a complex protective system comprising physical, chemical, microbial, and immune barriers, with tight junction proteins being a critical element ( Under normal conditions, protected by tight junction proteins, the gut barrier prevents the passage of intestinal pathogens ( 3 which is hydrolyzed to NH 4 OH, raising the intestinal pH