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Mast cells play an important role in inflammatory pathogenesis such as anaphylactic reactions, asthma, allergy, arthritis, cardiovascular diseases, systemic mastocytosis, interstitial cystitis, psoriasis, atopic dermatitis, cancer and metastasis, endometriosis, obesity, ulcers, prostatitis, periodontitis, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) (Sant et al., 2007

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The second hexa-histadine tag of the protein was not utilized in these experiments, but is relevant and must be noted because Ni-NTA was used to purify the GST-GFP for several of the experiments being discussed