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However, in the large QLQX trial, many patients were on digoxin and no increased toxicity was reported, suggesting its generally safe

Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

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A few reports showed that GSH content is increased in response to metal exposure due to the enhanced activities of proteins responsible for GSH biosynthesis (Xiang and Oliver 1999)