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These nanocarriers can be combined with other techniques, such as application of an external magnetic field in the case of magnetic nanoparticles or focused ultrasound in general, to further improve their passage across the BBB

It does this by influencing the production of melanin (the pigment in your skin)

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Spermatogenesis 1 , 231239 (2011)

Any correction protocol that exfoliates and treats without restoring the barrier leaves the tissue exposed to exactly the kind of environmental aggression that triggered the pigmentation in the first place