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In silico studies have proved that shogaol, demethoxycurcumin, capsaicin, ellagic acid, 6paradol, 6gingerol, carnosic acid, and curcumin can bind strongly with human DNA TOP3A and act against TOP3A [188] (Table 2)

The SF3B1 mutation leads to aberrant alternative splicing of estrogen-related receptor gamma (ESRRG), resulting in ESRRGs stronger affinity for pituitary-specific positive transcription factor 1 and leading to lactotroph cells proliferation and PRL hypersecretion

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

stir until fully dissolved (this may take 23 minutes)

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