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These are collectively referred to as parkinsonism (1), and they are the result of the progressive loss of dopaminergic neurons in substantia nigra (2) along with the formation of Lewy bodies that comprise misfolded -synuclein in the neurons (3)
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In transmethylation, SAMe donates its methyl group to a large variety of acceptor molecules in reactions catalyzed by methyltransferase (MTs)
J Neurochem 70:14211430 Bains JS, Shaw CA (1997) Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death
Prepare working stocks at required concentration, aliquot into single-use volumes, and store at -80C
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