Watch for signs of over-exfoliation: persistent redness, increased sensitivity, peeling, or that tight, uncomfortable feeling
Unique cases of angioedema (2 days after injection), cutaneous hypersensitivity (within 10 months on treatment), bullous pemphigoid (within 2 months on treatment), eosinophilic fasciitis (within 2 weeks on treatment), and leukocytoclastic vasculitis (unclear timing), most of which resolved after discontinuation, also were reported
Endocrinology 150 (1), 220231
Based on proteome analysis of mucus-grown A
(USA), now called Zynerba Pharmaceutics, have studied parent drug labile derivatives, CBD-esters and -carbonates among others, that can permeate the stratum corneum and, once they cross it, quickly separate back into the parent drug [224, 225]