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Under ER stress, the integrated stress response (ISR) pathway is activated, leading to the phosphorylation of eIF2 and subsequent upregulation of ATF4, a transcription factor that increases CHAC1 expression

It is commonly accompanied by hyperlipidemia which results from a disbalance between the rates of fatty acids synthesis and degradation and is characterized by elevated total cholesterol and low-density lipoprotein-cholesterol (LDL-C), thus providing the substrate for ROS-mediated lipid peroxidation (6366)

This binding might facilitate increased transcription of neurogenic differentiation genes

non-denatured GSH in the presence of 0.16% APTES are shown in Fig

Psychiatry 75 , e308e316 (2014)