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For example, the general applications of adeno-associated virus-based gene therapy are hampered by pre-existing humoral immune responses against the viral vectors [350,351,352], which for some viral serotypes occur in up to 60% of the population because of early-life infections [353, 354]

Cho N, Shaw J, Karuranga S, Huang Y, da Rocha FJ, Ohlrogge A, et al

Its main job is to increase insulin after meals and slow down stomach emptying

Even so, the extract still changed how genes linked to mitochondrial function responded , pointing to other mechanisms that were not directly measured