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Since MC4R-mediated suppression of appetite is at the level of PVH neurons projecting to the non-CGRP-expressing neurons in the lPBN [160], these findings suggest that RYGB targets this pathway

10.1152/ajpendo.00576.2005 56 MovahednasabM.Dianat-MoghadamH.KhodadadS.NedaeiniaR.SafabakhshS.FernsG.et al (2025)

However, it is important to adopt a balanced approach and seek professional guidance to tailor nutritional and supplementation strategies to individual needs