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First, Id like to say that I prefer the term MTHFR gene variation rather than mutation. The word mutation makes it sound like theres something wrong with the person, while variation is more empowering and in my opinion, also more accurate

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Furthermore, sustained inflammation can lead to structural changes within the hippocampus, including reduced dendritic spine density, alterations in synaptic protein expression and changes in neuronal connectivity patterns (Perry, 2010)

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Propionyl-L-carnitine : This form is good for people with circulatory issues, such as peripheral vascular disease or high blood pressure