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GLP-1s are entering that third phase where the business model around the molecule matters as much as the molecule itself

doi: 10.1124/pr.108.000604 3 GrrizJLSolerMJNavarro-GonzlezJFGarca-CarroCPuchadesMJD'MarcoLet al

Indications: type II diabetes mellitus a supplement to sulfonylurea or insulin therapy Contraindications: type 1 diabetes or for the treatment of diabetic ketoacidosis patients with a history of heart failure active liver disease (or elevated transaminase levels) - due to increased risk of hepatic injury Pharmacokinetics: metabolized through the hepatic cytochrome P450 system FDA Warnings / Safety Concerns & Availability Issues: Several previous clinical trials suggested that rosiglitazone (but not pioglitazone) may increase the risk of myocardial infarction

When the same area receives repeated injections, scar tissue and lipodystrophy can develop beneath the skin surface, invisible to the eye but tangible to the touch

Neurogastroenterol Motil (2004) 16(Suppl 2):316.10.1111/j.1743-3150.2004.00553.x 135 DuraffourdCDe VadderFGoncalvesDDelaereFPenhoatABrussetBet alMu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake