Consistently, hES-MSCs cultured at 5 10 3 cells/cm 2 (hereafter referred to as high-density) showed enhanced stem cell functions compared to those of cells cultured at 2 10 3 cells/cm 2 (hereafter referred to low-density) from all aspects, including stem cell marker expression, migration, and CFU (Fig
The proposed cellular mechanisms likely reverse over 6 to 12 months after discontinuation
(7) Yanqing Li, Chi Zhang, Haicheng Cheng, LinYan Lv, et al (2024) FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells Experimental Gerontology
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additionally, claudin-1 shows compensatory upregulation (Fig