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There is evidence strongly supporting the use of SGLT2 inhibitors in patients with HF or CKD independently of the presence or absence of T2DM [52,54]

A recent phase three program showed it improved A1C (a three-month average of blood sugar) more than comparators [the drugs it was tested against] and led to significant weight loss, with side effects mostly in the digestive tract (nausea, vomiting [and] diarrhea), like other GLP-1 drugs. Wegovy pill Orforglipron isnt the only pill-form GLP-1 generating excitement

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Tomimoto A, Endo H, Sugiyama M, et al