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Common adverse effects of GLP-1 receptor agonists include: Gastrointestinal symptoms : Nausea, vomiting, diarrhoea, constipation, and abdominal pain affect 30-50% of users, typically improving over time [20] Injection site reactions : Redness, itching, or discomfort at injection sites Gallbladder problems : Increased risk of cholelithiasis (gallstones) and cholecystitis Pancreatitis : Rare but serious risk requiring immediate medical attention if severe abdominal pain develops Hypoglycemia : Particularly when combined with other diabetes medications Additional important safety considerations include avoiding use during pregnancy and breastfeeding, risk of dehydration and acute kidney injury, and potential worsening of diabetic retinopathy in people with diabetes

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20 Similarly, epidemiological patterns in South America indicate a gradual increase, albeit at a slower rate

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