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The administration of liraglutide significantly attenuated PCOS-associated ovarian MGCs apoptosis in a concentration-dependent manner, and these effects were associated to modifications of the phosphorylation sites of forkhead box protein O1 (FoxO1), a negative regulator of cell survival

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These symptoms often improve over time with continued use in most patients, and NPs can reduce discontinuation by starting at a low dose and titrating gradually

Greater on-treatment weight loss was associated with a lower likelihood of GLP-1 RA discontinuation