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Abbreviations NPs: Nanoparticles BBB: Bloodbrain barrier CNS: Central nervous system CSF: Blood-cerebrospinal fluid PD: Parkinsons disease AD: Alzheimers disease BCSFB: Bloodcerebrospinal fluid barrier MS: Multiple sclerosis BCRP: Breast cancer resistance protein MRPs: Multidrug resistance-associated proteins ECs: Endothelial cells TJs: Tight junctions AJs: Adherent junctions CAMs: Cell adhesion molecules References Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ

Singh, H

Weekly vs daily administration Efficacy comparison (20.9% vs 5-8%) Step therapy requirements Teen patient considerations Ozempic vs Mounjaro Diabetes Focus Both FDA-approved for diabetescompare off-label weight loss and coverage

The active site in each subunit is known to be composed of two definite functional regions

Detectable medication levels can linger for five to seven weeks after the last injection