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Intravenous adenosine acts within 1530 seconds, with erythrocytes and vascular endothelial cells absorbing and metabolizing it through adenosine deaminase (ADA), leading to a short half-life (t) of less than 10 seconds (11)

Women using oral contraceptives should use a backup non-oral or barrier method for 4 weeks after starting Zepbound and after each dose increase due to potential reduced effectiveness of oral contraceptives

As such, therapeutic strategies targeted on these events may not be beneficial at last, a concern that has been reflected in certain preclinical studies

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