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Temporary skin darkening (hyperpigmentation) can occur, especially in those with darker skin tones and those with tanned skin, but this side effect is uncommon if specialized lasers for darker skin are utilized

A 250 mcg target amount equals 0.1 mL, or 10 insulin units

The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)

If left untreated, vitamin B deficiency may increase your risk of certain complications , including: anemia digestive issues skin conditions infections peripheral neuropathy Vitamin B12 deficiency, in particular, may increase your risk of neuropsychiatric disorders