The Trulicity segment dominated the market with a share of 31.72% in 2025 owing to its strong global market presence, convenient weekly dosing regimen, extensive clinical validation, and broad physician acceptance
Notably, small peptides like GLP-1 are challenging to obtain through conventional expression and purification systems, due to their low molecular weight and vulnerability to degradation
If this theory is correct, the prevention strategies outlined (conservative dosing, dose splitting when appropriate, adequate protein, electrolyte support, caloric floors, methylated B-vitamin support) should dramatically reduce that 20.9% incidence
It is marketed as a safe and affordable alternative to GLP-1 shots, which can be painful, expensive, and cause a variety of long and short-term side effects
While this study offers valuable insights, it also underscores the need for further research to explore additional outcomes beyond weight loss