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In rat ovaries (Figure 1) ( ex vivo models, where the high concentrations of GH caused excessive growth of theca cells, such that they depleted nutritional elements in the medium ( in vitro study, where high doses of GH were found to be harmful to rat preantral follicle survival, possibly due to excessive theca and stromal cell proliferation and subsequent nutrient depletion ( Interaction of FSH and LH with their complementary gonadotropin receptors (i.e., FSHR and LHR) induces downstream signaling that is critical for steroidogenesis, proliferation, and differentiation, and both signal through the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway to enhance production of E2 and P4 (Figure 2)

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2 The RCTs evaluated the adjusted dose of rivaroxaban and edoxaban in patients with AFib and CrCl 30-50 mL/min for stroke prevention