Since the mutagenesis of M3 disrupted 1 putative WD40 out of 2, we also mutagenized this second site (M5) and both M3 and M5 motifs and found a reduction in WIPI2 as well as ATG16L1 binding and the absence of BCAS3 interaction (Figure 7C)
Soluble oligomeric A aggregates have been shown to bind specifically to synapses in differentiated hippocampal neuronal cultures
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Even without such combinations, alcohol can irritate the gastrointestinal tract, and since nausea, vomiting, and gastrointestinal discomfort are among the most commonly reported side effects of GLP-1-based therapies, alcohol consumption may worsen these symptoms
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