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Human data is older, sparse, and conflicting

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique

A study published in the Proceedings of the National Academy of Sciences found that aging is associated with a 47% decrease in the catalytic subunit (GCLC) and a 52% decrease in the modulatory subunit (GCLM) of glutamate-cysteine ligase, the rate-limiting enzyme for glutathione production

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