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doi: 10.1155/2020/7897240 185 RathSHeidrichBPieperDHVitalM

Artemisinin activation is decreased in PfK13 mutant lines Artemisinin requires activation by free heme, thus we anticipated that the decrease in heme levels observed in 3-6 hpi ring-stage parasites would result in decreased artemisinin activation and, therefore, decreased activity

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Glycine can be interchanged with serine 41 , and glutamate can be converted to glutamine 42