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Two main conclusions can be made from this set of experiments: 1) sequence substitutions close to the N-termini of both parent peptides consistently result in a linked set of in vitro and in vivo agonist characteristics with the potential to improve their therapeutic properties, and 2) this effect is most marked for exendin-4, for which the differences between -phe1 and -asp3 analogues was generally greater than for lixisenatide

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[DOI] [PubMed] [Google Scholar] 62.Resende P.E., Verza S.G., Kaiser S., Gomes L.F., Kucharski L.C., Ortega G.G

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