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Exendin-4 (Ex-4), another GLP-1RA that is homologous to commercially available exenatide, ameliorated IR in primary neurons through insulin receptor substrate-1 (IRS-1), AKT, and glycogen synthase kinase-3 (GSK-3) pathways

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While the opportunity for oral GLP-1s is substantial, realising its full potential will depend on how effectively pharmaceutical companies and CDMOs navigate the associated challenges

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Standard aseptic technique applies: skin cleaned with an appropriate antiseptic, single-use needles, and a documented batch record kept against the patients notes in case of a later reaction or product recall