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Mechanism of Action Glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 (Figure 1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic cells [10]

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Leaky gut sounds a bit woo-woo, but its simply another term for a very real physiological phenomenon: increased intestinal permeability