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Brunilda Nazario, chief medical officer of medical affairs at WebMD told Flow Space

In humans, GLP-1 secretion in response to duodenal glucose delivery does not become robustly stimulated until the delivery rate overcomes the absorptive capacity of the duodenum, i.e

In SUSTAIN 3, the estimated treatment difference (semaglutide 1.0 mg vs exenatide ER) for reduction in body weight was particularly large in the MET + SU subgroup, driven mainly by a small body weight reduction with exenatide ER in this subgroup, rather than by a difference in the semaglutide effect between subgroups

J Am Med Dir Assoc 2020;21:300-7

Some factors that might support continuing treatment include: Youve lost substantial weight and want to maintain your results You have a history of weight cycling or difficulty maintaining weight loss You still have weight-related health concerns even at your current weight Your doctor believes stopping treatment would be detrimental to your overall health Can I switch to Wegovy if my BMI is below 30