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As expected, in contrast to Dpp4 hep/ , Dpp4 EC/ mice had no decrease in hepatic Dpp4 mRNA expression (Supplemental Figure 2H), and, consistent with previous reports (38), systemic fasting plasma DPP4 activity and DPP4 protein levels (Supplemental Figure 2, I and J) were significantly decreased in Dpp4 EC/ mice compared with controls

Tirzepatide activates both GLP-1 and GIP receptors, producing greater appetite suppression and metabolic effects than single-agent GLP-1 drugs

The preserved pulsatile GH pattern maintains physiological signaling that optimizes tissue repair without the complications associated with continuous hormone elevation

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