In a head-to-head trial against semaglutide (the SURPASS-2 trial), tirzepatide produced significantly greater weight loss, with participants taking the highest dose of tirzepatide losing an average of 11.2 kg (24.7 lbs), compared to 5.7 kg (12.5 lbs) for those taking semaglutide 1 mg
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doi: 10.1176/appi.ajp.20250289 25 MorleyK
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
Perhaps most notably for many patients, GLP-1 receptor agonists act on appetite centers in the brain, promoting satiety and reducing food intake
