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It needs medical oversight, clear protocols, and a compliant, documented supply chain

Indeed, it was shown that proglucagon expressing cells, derived from the colon of Venus mice cultures, were not responding significantly to Sucralose (1 mM) in terms of both released GLP-1 and intracellular Calcium

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Two investigators (HW and TG) independently performed the data extraction from each publication using a standardized form: publication data, baseline characteristics of the study population (sample size, sex, age, body mass index (BMI), body weight, abdominal circumference, waist-to-hip ratio, visceral adipose tissue (measured by computed tomography, magnetic resonance imaging, or dual-emission X-ray absorptiometry)), duration of follow-up, weight change during treatment and after treatment discontinuation, description of the weight management group and control group

Nat Rev Endocrinol 8, 728742 (2012)