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Fen-Phen was helping people with weight-loss but it was also found to be causing issues with heart valves

reported that injectable semaglutide therapy resulted in greater BW loss in patients with GLP-1 RAnave T2DM than in those who had already been treated with other GLP-1RAs and then switched to injectable semaglutide therapy [40]

Its only controlled human trial a Phase II study for postoperative ileus failed its primary endpoint , and clinical development was discontinued [5]

The study also found that the longer subjects were treated with these medications, the greater their risk of developing wet AMD

Instead, the interest is mostly indirect: GLP-1s may help with weight, insulin resistance, and inflammation, which can shape the metabolic environment in which hormone receptor-positive breast cancers develop or recur