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GLP-1 has been tested as a regulator of anxiety behavior and both GLP-1 and exendin-4 (administered ip , into the lateral ventricle or intra-dorsal raphe) induced anxiety-like behavior, which was measured in the black and white box, elevated plus maze and open field tests in Spraque-Dawley rats [86]
Immunoblotting was performed using biotinylated Phos-tag zinc complex BTL111 (Wako, Osaka, Japan) and anti-ABI5 antibody (ABclonal) 50
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Supplements recommended for GLP-1 users can address common nutritional gaps
There are no controlled trials of microinfusion-delivered peptides and growth factors in pregnancy, and the regulatory and clinical default in the absence of safety data is non-intervention
Science 333 , 12621266 (2011)
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