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Further analysis revealed that IBS-D patients had significant decrease of Lactobacillus and Bifidobacterium , as compared to their healthy counterparts and constipated-predominant IBS patients

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Secondary outcomes included nonfatal MI, nonfatal stroke, HHF and renal composite outcome, defined in most trials as a composite of progression to end-stage renal disease or a sustained decrease of at least 40% in estimated glomerular filtration rate (eGFR)

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