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393 For example, a recent RCT reported that buprenorphine outperforms diclofenac, significantly reducing fentanyl requirements, prolonging pain-free intervals, and improving VAS scores, with similar safety profiles, highlighting its potential as a first-line analgesic

Fulton RE, Pearson-Smith JN, Huynh CQ, Fabisiak T, Liang LP, Aivazidis S, High BA, Buscaglia G, Corrigan T, Valdez R, Shimizu T (2021) Neuron-specific mitochondrial oxidative stress results in epilepsy, glucose dysregulation and a striking astrocyte response

The authors would like to acknowledge the funding from the Ongoing Research Funding Program, (ORF-2026-371), King Saud University, Riyadh, Saudi Arabia

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