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Consumers should approach such products with appropriate skepticism and recognize the fundamental difference between evidence-based medications and dietary supplements

Many patients achieve their target weight and sustained appetite reduction at 1 mg or 1.7 mg and report better tolerability at these levels than at 2.4 mg

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Ependymal cells, as BBB components, downregulate tight junction proteins (e.g., zonula occludens-1 (ZO-1)) under inflammatory (TNF-) or -syn attack, allowing peripheral pro-inflammatory cytokines (e.g., IL-6), iron/copper ions, and immune cells (e.g., macrophages) to infiltrate the brain parenchyma [272]

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