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Structurally, Retatrutide is derived from the glucagon peptide backbone and incorporates targeted amino acid substitutions that improve resistance to enzymatic degradation while maintaining receptor binding capability

The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression

The FDA clinical studies were focused around correction of moderate to severe facial wrinkles and folds, such as nasolabial folds in adults over the age of 21

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