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However, both drugs can affect appetite, nausea, and gastrointestinal function, which means patients may experience overlapping or intensified side effects

Never discontinue prescribed medications without medical guidance, as abrupt cessation may affect metabolic control and weight management progress

87 Although this review revealed orlistat to be the most frequently studied non-GLP-1 AOM, global guidelines generally discourage its use as a first-line therapy due to its GI side effects

Michael Uzmann, a physician dual board-certified in internal medicine and endocrinology, the results of this study arent surprising, given that we know from previous research that the GLP-1 semaglutide has the same effect when combined with MHT