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As geriatric medicine specialists, endocrinologists, and obesity medicine physicians have noted in growing public commentary, prescribing a powerful weight-loss drug to a 70-year-old patient carries a fundamentally different risk profile than prescribing the same drug to a 45-year-old with the same BMI

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The results for orforglipron, an oral glucagon-like peptide-1 (GLP-1) receptor agonist, show less dramatic weight loss than injectable medications but are still clinically meaningful, according to the manufacturer Eli Lilly

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