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25 To a lesser extent, this same phenomenon has been reported in studies of aggressively treated type 2 diabetic patients and in obese diabetic patients treated with bariatric surgery that resulted in a lowering of hemoglobin A1c along with weight loss

In humans theres essentially no data on half-life, mechanism, or long-term side effects (source)

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The trial endpoints include both traditional AD outcomes (e.g., cognition, brain imaging, AD fluid biomarkers) and gold standard aging measures (e.g., frailty, physical function, epigenetic age, etc.)