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The gut microbiome plays a pivotal role in influencing liver function, highlighting the intricate interplay between the two organs through the Gut-Liver Axis (45)

Intravenous NR or NMN administration in mice results in rapid conversion into circulating NAM and NAD + boosting in liver, kidney, skeletal muscle, while NAD + in these organs after oral administration increases to a lower magnitude 39,69

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