GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and regulatory T cells, resulting into the inhibition of inflammatory responses and the promotion of neuronal regeneration through interleukin-10 secretion
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Superposition of PF-06372222-bound crystal structure (containing the C347 6.36b F mutation), with crystal structure based molecular dynamic simulations of F347 shown in blue (500 ns) and of simulations C347 (6.36b mutated back to cysteine) shown in pink (500 ns)
(28) The study included 1,222,436 patients with type 2 diabetes who were newly prescribed SGLT-2 inhibitors, GLP-1 agonists, DPP4-Is, or older antidiabetic agents (metformin, sulfonylureas, alpha glucosidase inhibitors, thiazolidinediones), with patients categorized based on their first recorded prescription