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For a 100kg person, this means minus 22-23 kg results previously only possible after bariatric surgery

Vitiello.Journal of Anti-Aging Medicine.Dec 2001.331-343

Of the 342 OPTIMA participants who completed the study, 249 have sleep annotation data from the Apple Watch and are included in this analysis

Relative contraindicationsconditions requiring closer monitoring or specialist inputinclude significant kidney impairment, active gastrointestinal disease, recent bariatric surgery, or concurrent use of certain medications that affect satiety or glucose metabolism