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Research published in JCI Insight describes tirzepatide as an "imbalanced and biased" dual agonist, meaning it shows equal affinity for the GIP receptor compared to native GIP but approximately 5-fold weaker affinity for the GLP-1 receptor compared to native GLP-1

If the injury is resolving well, most patients complete the full cycle and then take a two to four week break before evaluating whether a second cycle is needed