10.1080/0005772X.1999.11099415 31 HansenM.FlattT.AguilaniuH
9,16 When ingested without food, plasma levels of isotretinoin are reduced by approximately 60 percent compared with levels achieved when taken with a high-fat meal, 16 which could adversely affect efficacy, especially long-term remission of AV
Granitzer S, Ellinger I, Khan R, Gelles K, Widhalm R, Hengstschlger M, Zeisler H, Desoy G, upov L, ekov M, Salzer H, Gundacker C (2020) In vitro function and in situ localization of multidrug resistance-associated protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta
J Am Soc Nephrol 2019;30:2229-42.ArticlePubMedPMC 43
These findings are not identical to human pregnancy risks, but they form the basis for precautionary FDA guidance recommending discontinuation before conception