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GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help

PMID: 140 MaRGanLGuoJPengZWuJHarrisonARet al

The deprotonated forms of Lys and Arg with lower pKbs are much stronger bases than the deprotonated form of His, so at physiological pH, they would always be protonated (unless their local environment lowers their pKa and pKb values)

For example, a 2017 study on diabetic rats found that berberine may have an impact on intestinal health, but further research is needed to better understand its effects on intestinal permeability

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